I am using ISNULL in MS SQl server 2008, since my table is too huge, whether using of ISNULL may cause any thing to the performance ?.
ISNULL
Than
As it has been already mentioned it depends on how and where you are using it in your query. May be you might want to show the way you are using it in your query.
Also I would recommend you to go over this - What makes a SQL statement sargable?