I have a .NET 3.5 desktop application that had been showing periodic slow downs in functionality whenever the test machine it was on was out of the office.
I managed to
In this blog posting (which cites another source) you have two options: disable CRL checking system wide or per app:
Disable CRL Checking Machine-Wide Control Panel -> Internet Options -> Advanced -> Under security, uncheck the Check for publisher's certificate revocation option
Disable CRL Checking For a Specific .Net Application See this Microsoft KB Article: http://support.microsoft.com/kb/936707