Update 2019: No IE actually supports WebRTC and no IE ever will. In 5 weeks Microsoft Edge will die and long live Chromium based Edge.
That supports WebRTC.
For now IE doesn't support WebRTC.
Microsoft has some plans to implement WebRTC in the future, once ORTC APIs are added on top of WebRTC (also known as WebRTC 2.0).
The Chrome Frame plugin for IE has been discontinued, so that's not a good solution either.
The best option out there for now, is adopting Temasys' plugin for IE and Safari. It is free for use anywhere and adheres to the native WebRTC APIs. More information about it here: http://bloggeek.me/temasys-free-webrtc-plugin/