it is very easy to access master page control from content page like
protected void Page_Load(object sender, EventArgs e)
{
// content page load event
C# code within Site.Master:
Code within Site.Master.cs:
public partial class SiteMaster : MasterPage
{
protected void Page_Load(object sender, EventArgs e)
{
ToolkitScriptManager1.RegisterPostBackControl(this.MainContent.FindControl("btnOnDefaultPage"));
}
}
This is an example how a client control on the Default.aspx is referenced from a Site.Master.cs