I get error message \"Unable to start debugging on the web server\" in Visual Studio 2010. I clicked the Help button and followed the related suggestions without success.
I had the same issue on Win7 and VS2010 (without ReSharper) and found that Skype listened on port 80. IIS listens to port 80 by default. This can occur when you set VS to debug an existing web application running in IIS instead of the built in ASP.NET debug web server.
I solved the issue by unchecking "Use ports 80 and 443 as alternatives for incoming connections." in Skype under Tools -> Options -> Connection, followed by a restart of Skype.