I get error message \"Unable to start debugging on the web server\" in Visual Studio 2010. I clicked the Help button and followed the related suggestions without success.
I had this problem in Visual Studio 2012 when running a website I had created in Visual Studio 2010. I tried each of the following, which did not solve the problem, but still may have been required:
Checked that the App Pool was targeted to the same framework as what was specified in the web.config
Started the 64bit Remote Debugger: \Program Files (x86)\Microsoft Visual Studio 11.0\Common7\IDE\Remote Debugger\x64\msvsmon.exe
Set the DisableLoopbackCheck registry key and restarted Windows. MS Instructions here
Browsed the site locally (it came up just fine).
Finally I found the IIS setting that fixed the issue.