I get error message \"Unable to start debugging on the web server\" in Visual Studio 2010. I clicked the Help button and followed the related suggestions without success.
I had the same problem. How did I fixed it.
Go to IIS (in my case IIS 7 / Windows 7). Select your web site from the list, click on .NET Compilation in ASP.NET section. Select Open Feature. Check if your Debug is set to True. In my case it was False. Once I changed it to True - I have my debug back :)