psyco seems to be quite helpful in optimizing Python code, and it does it in a very non-intrusive way.
Therefore, one has to wonder. Assuming you\'re always on a x8
When using pyglet I found that I couldn't use psyco on the entire app without making my app non-functional. I could use it in small sections of math-heavy code, of course, but it wasn't necessary, so I didn't bother.
Also, psyco has done strange things with my profiling results (such as, well, not alter them at all from the non-psyco version). I suspect it doesn't play nice with the profiling code.
I just don't really use it unless I really want the speed, which is not all that often. My priority is algorithm optimization, which generally results in nicer speedups.