For the purpose of identifying [possible] bot-generated usernames.
Suppose you have a username like \"bilbomoothof\" .. it may be nonsense, but it still contains pro
Just use CAPTCHA as a part of the registration process.
You can never distinguish real uesrnames from bot-created usernames, without severely annoying your users.
You will block users with bizzare, or non-English names, which will irritate them, and the bots will just keep trying until they catch a good username (from dictionary, or other sources - this is a very nice one, by the way!).
EDIT : Looking for prevention rather than after-the-fact analysis?
The solution is letting somebody else manage user's identities for you. For instance, you can use a small list of OpenID providers (like SO), or facebook connect, or both. You'll know for sure that the users are real, and that they have been solving at least one CAPTCHA.
EDIT: Another Idea
Search the string in Google, and check the number of matches found. Shouldn't be your only tool, but it is a good indicator, too. Randomized strings, of course, should have little or no matches.