I have several tables whose only unique data is a uniqueidentifier (a Guid) column. Because guids are non-sequential (and they\'re client-side generated so I can\'t use news
A Primary Key needn't be an autoincrementing field, in many cases this just means you are complicating your table structure.
Instead, a Primary Key should be the minimum collection of attributes (note that most DBMS will allow a composite primary key) that uniquely identifies a tuple.
In technical terms, it should be the field that every other field in the tuple is fully functionally dependent upon. (If it isn't you might need to normalise).
In practice, performance issues may mean that you merge tables, and use an incrementing field, but I seem to recall something about premature optimisation being evil...