I have been trying unsuccessfully to profile my device (via Instruments) using the latest version of Xcode 7.0.1 (7A1001 released 9/28), as well as the previous version of X
According to Apple staff on the developer forums the behaviour of this issue is greatly improved in the Xcode 7.3 betas, so one easy solution is to try upgrading Xcode. I've upgraded and it seems to be behaving so far.