I open my project in Xcode 6.1. When I try to run the project, the button is grayed out. When I try to go to Product > Clean, the option is grayed out. When
Same Problem happened with me.. When I updated from Xcode 8 Beta 3 to Xcode 8 Beta 4, But I resolved it by this way..
you can see all Devices and Simulators here
If above does not work.. as if you do not see any simulators, then..
It worked for me.. Hope will be helpful for someone later..