I\'m currently trying to get MySQL working on OSX 10.7 Lion. I tried the brew way:
brew install mysql -> cmake -> no problems -> make
A drop in replacement for mysql is mariadb. You can install with 'brew install mariadb'. It builds on Lion.
Existing mysql drivers and clients just work. I'm using it with python-mysql and django.
It's even called mysql so you won't even know the difference.