Put the modifiers where they were meant to be: on either side of the space-bar, where they can be pressed by the thumb (or other digit of your choice) on the opposite hand from the digit pressing the modified letter (so that C-g is right-thumb on Ctrl and left index on 'g', and C-k is left-thumb on Ctrl and right middle on 'k'). You will note that the correct sequence, from inside out, is Ctrl Meta Super Hyper.
How you do this depends on your OS and your keyboard. For Windows, you might like to start here. In Mac OS X you can look in System Preferences > Keyboard & Mouse > Modifier Keys. For Linux, there are a thousand xmodmap and XKB tutorials.
