There are many ways, approach to do this.For that reason, I recommend to read carefully the article related to the deployment process on DjangoAdvent.com:
Eric Florenzano - Deploying Django with FastCGI: http://djangoadvent.com/1.2/deploying-django-site-using-fastcgi/
Read too:
Mike Malone - Scaling Django
Stochastictechnologies Blog: The perfect Django Setup
Mikkel Hoegh Blog: 35 % Response-time-improvement-switching-uwsgi-nginx
Regards