I really like the ability to edit javascript in the chrome debugger however, I find that it can be really problematic getting the debugger to re-fetch the JavaScript from th

The context menu shown above is accessible by right clicking / presssing & holding the "reload" button, while Chrome Dev Tools is opened.
Empty cache and hard reload works best for me.
Another Advantage: This option keeps all other opened tabs and website data untouched. It only reloads and clears the current page.