One reason - separating your domain model from your database model.
What I do is use Test Driven Development so I write my UI and Model layers first and the Data layer is mocked, so the UI and model is build around domain specific objects, then later I map these objects to what ever technology I'm using the the Data Layer. Its a bad idea to let the database structure determine the design of your application. Where possible write the app first and let that influence the structure of your database, not the other way around.
