You aren't including the actual variable information missing the quotations, like
VALUES ('" & usernme & '", ...etc
You should be using parameters to avoid errors and sql injection:
sqlQry = "INSERT INTO tbl_user (username, password) VALUES(@usernme, @passwrd)"
Dim cmd As New OleDbCommand(sqlQry, myconnection)
cmd.Parameters.AddWithValue("@usernme", usernme)
cmd.Parameters.AddWithValue("@passwrd", passwrd)
cmd.ExecuteNonQuery()