Answers (please read them below, their respective authors provided valuable insights):
You cannot write to an instance property if its prototype defines that property as unwritable (and the object instance doesn't have a descriptor) because the set operation goes up to the parent (prototype) to check if it can write, even though it would write to the child (instance). See EcmaScript-262 Section 9.1.9 1.c.i
4. If ownDesc is undefined, then
a. Let parent be O.[[GetPrototypeOf]]().
b. ReturnIfAbrupt(parent).
c. If parent is not null, then
i. Return parent.[[Set]](P, V, Receiver).
However, if you are trying to get around that, you can set the descriptor of the instance itself.
var proto = Object.defineProperties({}, {
foo: {
value: "a",
writable: false, // read-only
configurable: true // explained later
}
});
var instance = Object.create(proto);
Object.defineProperty(instance, "foo", {writable: true});
instance.foo // "b"