Excel Interop is removing images from processed files.
I’m using the Excel Interop, no third-party components are present (that I\'m aware of). The workflow is -- cr
You're probably on your own, since Excel isn't supported in a server environment as @Yahia correctly points out.
Your mention of ActiveX controls is a red flag - maybe some of your ActiveX controls require Excel to run under an account with a profile?
All you can do is debug this yourself, probably best to proceed by eliminating the possible sources of different behaviour in your dev and production environments.