We have a large VS 2010 solution that is mostly C# code but there are a few native DLLs that various C# projects depend upon (including our unit testing DLL). We\'re in the
Francesco Pretto has an extension that helps with this. It seems to have some quirks and deficiencies, but it's a start.
http://visualstudiogallery.msdn.microsoft.com/619d92a2-4ead-410d-a105-135f7b4b4df9
With source on github:
https://github.com/ceztko/SolutionConfigurationName