We have a large VS 2010 solution that is mostly C# code but there are a few native DLLs that various C# projects depend upon (including our unit testing DLL). We\'re in the
When I had to do this, I simply made all of my assemblies buildable as x86 or x64 rather than AnyCPU, and had two separate output packages. There's really no point in AnyCPU if you KNOW your process must be 32-bit or 64-bit a prori.