search multiple pattern in file and delete line if pattern matches

Question

For ex, a file contain contents:

10.45.56.84 raj
10.49.31.81 mum
10.49.31.86 mum
10.81.51.92 guj
10.45.56.116 raj
10.45.56.84 raj

I want to

Answer 1

Another solution:

 awk '!/10.45.56.84|10.81.51.92/' file