I saw the Get-NextFreeDrive function in this answer and I wondered if there was a more efficient way to do this. It appears that the function in the linked answ
I found to my own cost that the currently accepted answer (ls function:[d-z]: -n | ?{ !(test-path $_) } | random) can indeed return things like CD drives.
I've made this one to exclude any local drives from the array:
"$([char[]]([char]'D'..[char]'Z')|Where-Object {((Get-WmiObject -Class Win32_LogicalDisk).DeviceID).replace(':','') -notcontains $_ }|Select-Object -first 1):"
It will return the first available letter. If you'd prefer the last available letter just change Select-Object -first 1 to Select-Object -last 1