After upgrade from Pycharm 2017.2.3 to Pycharm 2017.1.4 Pycharm\'s Debugger suggested to build cpython (or sth associated with it):
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I agree with James.
I meet the same question as you after I install PYQT. After I uninstall pyqt by Pycharm's "Preference->Project:your current project->Project Interpreter" find pyqt and push '-' button, the debug works.
What is interesting is that when I run a script which includes 'from PyQt4 import QtGui'. The pyqt package installed auto. And the debug does not work again. So I uninstall pyqt again and debug works one more time!
So I think there may be some package make debug not work , what you should do is just find and uninstall it. The crime package is often the pyqt, matplotlib or something similary.