Many spreadsheets have formulas and formatting that Python tools for reading and writing Excel files cannot faithfully reproduce. That means that any file I want to create p
if you're talking about 'sheets' as 'tabs', then it is possible to modify just one of the tabs by accessing the particular one using the parse(sheet_name) function.
an example is here: Reading an Excel file in python using pandas
to write back to excel, (while controlling the sheets) use the to_excel function, here:
http://pandas.pydata.org/pandas-docs/stable/generated/pandas.DataFrame.to_excel.html