Re-assign/override hotkey (Win + L) to lock windows

Question

Is it possible to re-assign the Win+L hotkey to another executable/shortcut?

Use-case - I would like to switch off the monitor of my laptop as

Answer 1

Looks like you can't.

You can disable all built-in Windows hotkeys except Win+L and Win+U by making the following change to the registry (this should work on all OSes but a reboot is probably required):

HKEY_CURRENT_USER\Software\Microsoft\Windows\CurrentVersion\Policies\Explorer NoWinKeys REG_DWORD 0x00000001 (1)

(http://www.autohotkey.com/docs/misc/Override.htm)

But you could try using Tweak UI. Under the Explorer tree view item, uncheck "Enabled Windows+X" hotkeys. Hoekey also might work, haven't tried it. Source.