ASP.NET CheckBox does not fire CheckedChanged event when unchecking

Question

I have a CheckBox on an ASP.NET Content Form like so:

Answer 1

Additionally: Check for any errors in the JavaScript console.

I experienced the same exact issue described by OP except that it only happened in Safari (checkbox worked fine in Chrome and Firefox). Upon inspecting the JavaScript console, I found an error that was being thrown by a malformed jQuery selector.

In my case, I had $('a[id*=lbView') which was missing a closing ]. This threw an error in Safari but, surprisingly, not in Chrome nor in Firefox.