I have these MySQL tables:
table1:
id | writer
1 | Bob
2 | Marley
3 | Michael
table2:
user_one | user_two
You could use the following query:
SELECT table1.id
FROM table1
LEFT JOIN table2
ON table1.id IN (table2.user_one, table2.user_two)
WHERE table2.user_one IS NULL;
Although, depending on your indexes on table2 you may find that two joins performs better:
SELECT table1.id
FROM table1
LEFT JOIN table2 AS t1
ON table1.id = t1.user_one
LEFT JOIN table2 AS t2
ON table1.id = t2.user_two
WHERE t1.user_one IS NULL
AND t2.user_two IS NULL;