It seems like ASP.NET 4.0 is not prepared to handle ImageButton events triggered by Internet Explorer 10. The problem is that IE10 sends the image click coordinates as doubl
Here's a JavaScript workaround. It overrides the existing method, floors the x and y coordinates then calls the existing method with these new coordinates.
Sys.WebForms.PageRequestManager.getInstance()._origOnFormActiveElement = Sys.WebForms.PageRequestManager.getInstance()._onFormElementActive;
Sys.WebForms.PageRequestManager.getInstance()._onFormElementActive = function(element, offsetX, offsetY){
if (element.tagName.toUpperCase() === 'INPUT' && element.type === 'image'){
offsetX = Math.floor(offsetX);
offsetY = Math.floor(offsetY);
}
this._origOnFormActiveElement(element, offsetX, offsetY);
};