I have used a static global variable and a static volatile variable in file scope,
both are updated by an ISR and a main loop and main loop checks the value of the varia
The "volatile" keyword suggests the compiler not to do certain optimizations on code involving that variable; if you just use a global variable, nothing prevents the compiler to wrongly optimize your code.
Example:
#define MYPORT 0xDEADB33F
volatile char *portptr = (char*)MYPORT;
*portptr = 'A';
*portptr = 'B';
Without "volatile", the first write may be optimized out.