By creating object like this
var condition= { where: { LastName:\"Doe\", FirstName:[\"John\",\"Jane\"], Age:{ gt:18 } }
Use Sequelize.or:
Sequelize.or
var condition = { where: Sequelize.and( { name: 'a project' }, Sequelize.or( { id: [1,2,3] }, { id: { lt: 10 } } ) ) };
Reference (search for Sequelize.or)
Edit: Also, this has been modified and for the latest method see Morio's answer,