A lot of the applications I write make use of lookup tables, since that was just the way I was taught (normalization and such). The problem is that the queries I make are of
For look-up tables I use a sensible primary key -- usually just a CHAR(1) that makes sense in the domain with an additional Title (VARCHAR) field. This can maintain relationship enforcement while "keeping the SQL simple". The key to remember here is the look-up table does not "contain data". It contains identities. Some other identities might be time-zone names or assigned IOC country codes.
For instance gender:
ID Label M Male F Female N Neutral
select * from people where gender = 'M'
Alternatively, an ORM could be used and manual SQL generation might never have to be done -- in this case the standard "int" surrogate key approach is fine because something else deals with it :-)
Happy coding.