The Microsoft .NET Framework 4.0 full installer (32- and 64-bit) is 48.1 MB and the Client Profile installer is 41.0 MB. The extracted installation files are 237&n
You should deploy "Client Profile" instead of "Full Framework" inside a corporation mostly in one case only: you want explicitly deny some .NET features are running on the client computers. The only real case is denying of ASP.NET on the client machines of the corporation, for example, because of security reasons or the existing corporate policy.
Saving of less than 8 MB on client computer can not be a serious reason of "Client Profile" deployment in a corporation. The risk of the necessity of the deployment of the "Full Framework" later in the corporation is higher than costs of 8 MB per client.