Python pandas has a pct_change function which I use to calculate the returns for stock prices in a dataframe:
ndf[\'Return\']= ndf[\'TypicalPrice\'].pct_chan
@poulter7: I cannot comment on the other answers, so I post it as new answer: be careful with
np.log(df.price).diff()
as this will fail for indices which can become negative as well as risk factors e.g. negative interest rates. In these cases
np.log(df.price/df.price.shift(1)).dropna()
is preferred and based on my experience generally the safer approach. It also evaluates the logarithm only once.
Whether you use +1 or -1 depends on the ordering of your time series. Use -1 for descending and +1 for ascending dates - in both cases the shift provides the preceding date's value.