What's the difference between F5 refresh and Shift+F5 in Google Chrome browser?

Question

What\'s the difference between F5 refresh and SHIFT+F5 in Google Chrome browser?

The reason I ask is because sometimes when using

Answer 1

Reload the current page:
F5
or
CTRL + R


Reload the current page, ignoring cached content (i.e. JavaScript files, images, etc.):
SHIFT + F5
or
CTRL + F5
or
CTRL + SHIFT + R