I am having a Web application sitting on IIS, and talking with [remote]Service-Machine. I am not sure whether to choose TCP or Http, as the main protocol.
more detai
You could always benchmark it.
In general, if what you want to accomplish can be easily done over HTTP (i.e. the only reason you would otherwise think about using raw TCP is for a possible performance boost) you should probably just use HTTP. Sure, you can do socket programming, but why bother? Lots of people have spent a lot of time and effort building HTTP client libraries and servers, and they have spent waaaaaay more time optimizing and testing that code than you will ever be able to possibly spend on your TCP sockets. There are simply so many possible errors that you would have to handle, edge cases, and optimizations that can be done, that it is usually easier and safer to use a library function for HTTP.
Plus, the HTTP specs define all kinds of features (and clients/servers implement, which you get to use "for free", i.e. no extra implementation work) which makes any third-party interoperability that much easier. "Here is my URL, here are the rules for what you send, here are the rules for what I return..."