I\'ve watched an already well known video where Bret Victor, former Apple UI designer shows amazing demos with immediate updates of running code after changing literally one
I believe the following allow changing a line in source (and seeing the immediate effects):
Note: I have experience only with 1, 5-7. For many of these, I don't think you can put your cursor on a certain part of the code and have the relevant portions of the image highlighted.
Edit: added items no. 4 (2014.10.27), 5 (2014.10.31), and 6-7 (2015.03.12).
Edit 2 (2015.06.25): from http://sixrevisions.com/tools/code-demo-sites/ (most of these are HTML/CSS/Javascript).