I have experimented with Lisp (actually Scheme) and found it to be a very beautiful language that I am interested in learning more about. However, it appears that Lisp is n
A fairly recent open-source project that is still enjoying consistent and considerable development activity is LilyPond.
It's a music notation program that takes a easy-to-write text file as input and converts it into beautiful sheet music (pdf files). Offers all kinds of ways to fiddle with the output if you want to. It can even produce decent sounding midi files. I use it whenever I need to produce nice sheet music that other musicians will read from. I think it's better than Finale and it's free!
In the commercial category, there is also Notehead's Igor Engraver. Unfortunately, the site doesn't allow me to post a direct link to the page that talks about Lisp, so go to downloads and look at the bottom for a "Lisp" link.
There's also Naughty Dog (a computer game company) who use Lisp in their games. This article talks about that and even shows some code.
And there are many others that have been mentioned and linked to, but these are the main ones that resonate with me (being a composer/programmer/gamer/... type).