If your ID column on a table is a unique identifier (Guid), is there any point creating a clustered primary key on the ID column?
Given that they a
The idea of having a sorted index is very good in itself as searching then becomes very efficient.
The problem however is that in case of a GUID one never searches with "WHERE GUID = xyz". So the whole concept is wasted. So I would suggest to rather have a clustered index on a column which is used most often as a SARG to increase the query efficiency.