I\'ve been digging through some parts of the Linux kernel, and found calls like this:
if (unlikely(fd < 0))
{
/* Do something */
}
o
They're hints to the compiler to generate the hint prefixes on branches. On x86/x64, they take up one byte, so you'll get at most a one-byte increase for each branch. As for performance, it entirely depends on the application -- in most cases, the branch predictor on the processor will ignore them, these days.
Edit: Forgot about one place they can actually really help with. It can allow the compiler to reorder the control-flow graph to reduce the number of branches taken for the 'likely' path. This can have a marked improvement in loops where you're checking multiple exit cases.