In my experience it seems that most people will tell you that it is unwise to force a garbage collection but in some cases where you are working with large objects that don\
Large objects are allocated on LOH (large object heap), not on gen 0. If you're saying that they don't get garbage-collected with gen 0, you're right. I believe they are collected only when the full GC cycle (generations 0, 1 and 2) happens.
That being said, I believe on the other side GC will adjust and collect memory more aggressively when you work with large objects and the memory pressure is going up.
It is hard to say whether to collect or not and in which circumstances. I used to do GC.Collect() after disposing of dialog windows/forms with numerous controls etc. (because by the time the form and its controls end up in gen 2 due to creating many instances of business objects/loading much data - no large objects obviously), but actually didn't notice any positive or negative effects in the long term by doing so.