In my experience it seems that most people will tell you that it is unwise to force a garbage collection but in some cases where you are working with large objects that don\
Suppose your program doesn't have memory leakage, objects accumulates and cannot be GC-ed in Gen 0 because: 1) They are referenced for long time so get into Gen1 & Gen2; 2) They are large objects (>80K) so get into LOH (Large Object Heap). And LOH doesn't do compacting as in Gen0, Gen1 & Gen2.
Check the performance counter of ".NET Memory" can you can see that the 1) problem is really not a problem. Generally, every 10 Gen0 GC will trigger 1 Gen1 GC, and every 10 Gen1 GC will trigger 1 Gen2 GC. Theoretically, GC1 & GC2 can never be GC-ed if there is no pressure on GC0 (if the program memory usage is really wired). It never happens to me.
For problem 2), you can check ".NET Memory" performance counter to verify whether LOH is getting bloated. If it is really a issue to your problem, perhaps you can create a large-object-pool as this blog suggests http://blogs.msdn.com/yunjin/archive/2004/01/27/63642.aspx.