I want to turn off the cache used when a URL call to a server is made from VBScript running within an application on a Windows machine. What function/method/object do I use
If you have control over the application targeted by the XMLHTTP Request (which is true in your case), you could let it send no-cache headers in the Response. This solved the issue in my case.
Response.AppendHeader("pragma", "no-cache");
Response.AppendHeader("Cache-Control", "no-cache, no-store");
As alternative, you could also append a querystring containing a random number to each requested url.