Within my webpage I have an iframe like so:
Yes you can. Say your iframe's ID is 'myIFrame'
Then, add the following in your JavaScript:
// Get the iframe
const iFrame = document.getElementById('myIFrame');
// Let's say that you want to access a button with the ID `'myButton'`,
// you can access via the following code:
const buttonInIFrame = iFrame.contentWindow.document.getElementById('myButton');
// If you need to call a function in the iframe, you can call it as follows:
iFrame.contentWindow.yourFunction();
Hope it helps :)