I have an IIS7.5 web-site, on Windows Server 2008, with an ASP.NET MVC2 web-site deployed to it. The website was built in Visual Studio 2008, targeting .NET 3.5, and IIS 5.1
Checkout if KB 2023146 applies to your scenario. Also try requesting directly a controller action: /yoursitename/home/index
/yoursitename/home/index