In general I avoid using the comma operator because it just makes code less readable. In almost all cases, it would be simpler and clearer to just make two statements. Like:
foo=bar*2, plugh=hoo+7;
offers no clear advantage over:
foo=bar*2;
plugh=hoo+7;
The one place besides loops where I have used it it in if/else constructs, like:
if (a==1)
... do something ...
else if (function_with_side_effects_including_setting_b(), b==2)
... do something that relies on the side effects ...
You could put the function before the IF, but if the function takes a long time to run, you might want to avoid doing it if it's not necessary, and if the function should not be done unless a!=1, then that's not an option. The alternative is to nest the IF's an extra layer. That's actually what I usually do because the above code is a little cryptic. But I've done it the comma way now and then because nesting is also cryptic.