A client wants to \"Web-enable\" a spreadsheet calculation -- the user to specify the values of certain cells, then show them the resulting values in other cells.
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It sounds like you're talking that the user has the spreadsheet open on their local system, and you want a web site to manipulate that local spreadsheet?
If that's the case, you can't really do that. Even Office automation won't help, unless you want to require them to upload the sheet to the server and download a new altered version.
What you can do is create a web service to do the calculations and add some vba or vsto code to the Excel sheet to talk to that service.