Have recently upgraded to Visual Studio 2013 Pro and am having some teething problems.
Primarily if I change any HTML or CSS in either a .aspx page for Web Forms or
I had the same issue today. I already had that setting on (Always Build). Cleaning & rebuilding the solution didn't do the trick. I looked under C:\Windows\Microsoft.NET\Framework\v4.0.30319\Temporary ASP.NET Files\ and I found a folder named root with a lot of temporary hexa-numeric named folders. Only one folder had today's date. I closed all VS 2013 windows and removed that folder. After I restarted VS 2013 I simply run the project and my changes are now back.