I have designed and developed more than 10 sites, but I still have a doubt about the correct unit I should use. Should it be px, em or %
If you're talking about font-size then px and pt are not ideal.
Ems and Percent units are scalable, therefore they are far more accessible - friendly for the visually-impaired. They also scale down well for mobile phone users.
Px and Pt units do not scale upward for visually-impaired users, or downward for mobile phones.
If you're talking about layout or containers then it depends on the type of design you want - fluid or static - and there isn't necessarily a "right" answer.
Without going into an example, it's difficult to advice. Do you have a site in mind we could look at?